No, machining with the Pocket NC V2 requires knowledge of CAD/CAM software. The CAD software allows you to program the 3D solid model of what you want to build, and the CAM portion of the software tells the machine how to cut the part. This is quite a bit different from uploading a file to a 3D printer and having the machine print it. The user of the Pocket NC V2 machine needs to tell the machine where to run the tools and also how fast to cut, there is some strategy to this. If you have 3D printing experience only and no CAD/CAM experience we recommend downloading the Autodesk Fusion 360 Ultimate 1-month trial and going through some of the CAD and CAM tutorials (there are several of them ranging in experience from beginner to advanced). There are also a plethora of tutorials available just over You Tube if you prefer. These will give you an idea of if this is something you would like to work to be proficient in.
Another thing to note is that some parts that are easily 3D printed cannot be machined well. For instance, the V2 may not make curved surfaces as well as a 3D printer. However, typically the CNC typically has better resolution and surface finish. It is important to understand these differences before switching from a 3D printer to a CNC machine or when selecting to make your part on one machine vs another.